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KMID : 1143820100060010031
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Anxiety and Mood
2010 Volume.6 No. 1 p.31 ~ p.36
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Abnormal Mismatch Negativity in Patients with Obsessive-Compulsive Disorder
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Jang Joon-Hwan
Shin Kyung-Soon
Son June-Hee
kwon Jun-Soo
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Abstract
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Objective : Mismatch negativity (MMN) provides an electrophysiological index of an involuntary attention switching process. This study investigated MMN anomalies and their relationship to clinical variables in patients with obsessive-compulsive disorder (OCD).
Methods: Study participants were 29 OCD patients and 24 normal controls. We used a 128-channel EEG to measure MMN during a passive oddball paradigm. Then we assessed the correlations between MMN amplitudes and clinical measures.
Results: The OCD patients exhibited significantly greater MMN amplitude compared to the controls. Also, the right frontal lobe MMN amplitudes correlated significantly to the OCD patients’ Yale-Brown Obsessive Compulsive Scale total scores (r=-0.520, p=0.005).
Conclusion: These results suggest that MMN anomalies in OCD patients reflect a monitoring circuit dysfunction, raising the possibility that the OCD’s pathophysiology includes glutamatergic dysfunction.
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KEYWORD
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Obsessive-compulsive disorder, Mismatch negativity, Event-related brain potential
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